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Transforming growth factor-beta (TGF-β) production analysed by enzyme immunosorbent assay (EIA) in supernatants from splenocytes incubated with murine rIL-6. A significant increase was seen with the lowest dose (5 ng/ml) of rIL-6, while no such increase was observed for splenocytes from wild-type mice. □, Splenocytes from IL-6-deficient mice; ▪, wild-type animals. Mean and s.e.m. are given.
