Fig. 1.
The effect of intravenous treatment with a monoclonal antibody to IL-8 on CSF WBC levels during experimental pneumococcal meningitis. WS-4/Tmp-1 (5 mg) was given as an intravenous bolus infusion over 1 h immediately after the intracisternal inoculation of approximately 106 CFU of Streptococcus pneumoniae, type 3 at 0 h (arrow). CSF WBC levels were significant attenuated in WS-4 treated rabbits (medians, closed symbols, solid line, n = 7) compared to rabbits treated with an isotype control antibody, Tmp-1 (medians, open symbols, dashed line, n = 6) between 10 and 16 h. *P < 0·05 (Mann–Whitney test). Bars indicate 25th and 75th percentiles.