Table 1.

The effect of intracisternal treatment with a monoclonal antibody to IL-8 (WS-4) on CSF WBC levels during experimental pneumococcal meningitis

Hours	Untreated control (n = 10) cells/µl	WS-4 treated 100 µg (n = 5) cells/µl	WS-4 treated 10 µg (n = 4) cells/µl	WS-4 treated 1 µg (n = 4) cells/µl	WS-4 treated 0·1 µg (n = 2) cells/µl
0	< 100 (< 100)	< 100 (< 100)	< 100 (< 100)	< 100 (< 100)	< 100 (< 100)
2	< 100 (< 100)	< 100 (< 100)	< 100 (< 100)	< 100 (< 100)	< 100 (< 100)
4	< 100 (< 100)	500 (< 100–700)	< 100 (< 100)	< 100 (< 100)	< 100 (< 100)
6	< 100 (< 100–1100)	400 (< 100–700)	741 (< 100–1300)	< 100 (< 100)	200 (< 100–400)
8	250 (< 100–1342)	390 (< 100–1200)	500 (400–2188)	650 (< 100–1200)	600 (400–800)
10	600 (< 100–1200)	500 (300–600)	1700 (500–2900)	650 (< 100–1700)	800 (800)
12	1200 (< 100–2100)	700 (300–2000)	1801 (600–3900)	700 (< 100–2000)	2100 (1300–2900)
14	1020 (300–8200)	1200 (300–4000)	2500 (600–4900)	2050 (300–2800)	2565 (2200–2931)
16	2550 (700–10900)	2550 (800–10000)	3800 (600–8700)	2150 (1100–3000)	3033 (2200–3867)

*All data are shown as medians and ranges (min − max). WS-4 was injected intracisternally immediately after the intracisternal inoculation of approximately 1 × 10⁶ CFU Streptococcus pneumoniae, type 3 (at 0 h). No significant difference was observed between WS-4 treated and untreated control rabbits at any time-point (P > 0·05 (Mann–Whitney test)).