Fig. 5.

Macroscopic features of skin reaction. (a) Dorsal skin. Sensitized guinea-pigs were administered s.c. with 10 pmol/kg rIL-5 into the ear lobe 12 h after challenge on the dorsal skin (right). Despite increased eosinophil infiltration into the dermis, macroscopic features were not altered compared with positive control animals (left). (b) Ear lobe. Sensitized guinea-pigs received 10 pmol/kg rIL-5 at the time of challenge (right). Inhibition of eosinophil recruitment reduced erythema and oedema, when compared with positive control animals (left).