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Pedigree of family A. Open symbols, no mutation at position −52 in CYBB; half-filled symbols, heterozygous C-52T mutation in CYBB; filled symbols, males with C-52T in CYBB. Patient II-2 was not investigated, because he had died before the start of our study; his mutation was deduced from the fact that his daughter but not his wife was heterozygous for the mutation.
