Fig. 2.

IL-10-induced platelet-activating factor (PAF) synthesis from active SLE monocytes. (a) PAF synthesis from monocytes unstimulated (▪) or stimulated with 20 ng/ml IL-10 (□). PAF was detected as being cell-associated. A statistical difference between the basal and stimulated PAF levels was observed in the active SLE patient group (n = 14, *P < 0·05) but not in the inactive (n = 14) or control (n = 15) groups. (b) PAF produced by monocytes (1 × 10⁶) derived from three active SLE patients stimulated with 20 ng/ml IL-10 (□) or with 20 ng/ml IL-10 preabsorbed with the anti-IL-10 antibody (hatched column). Inhibition of IL-10-induced PAF was observed after immuno-absorbtion of IL-10. *P < 0·05.