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Spontaneous and myelin basic protein (MBP) 68–86-induced nitric oxide (NO) production (a) in supernatants of cultured mononuclear cells (MNC) of lymph node and spleen, and inducible nitric oxide synthase (iNOS) expression (b) in spleen sections from dendritic cell (DC)-tolerized, DC-control and PBS-control EAE rats on day 14 p.i. (cf. legend to Fig. 1). Results are expressed as mean ±s.e.m. of four rats from two independent experiments (*P < 0·05; **P < 0·01; ***P < 0·001).
