Scheme 2a.
a Reagents and conditions: (a) TBSCl, imidazole, DMF (97%); (b) Boc2O, DMAP, CH3CN (97%); (c) TBAF, THF (99%); (d) (i) (COCl)2, DMSO, CH2Cl2 −65 °C: NEt3, (ii) (CF3CH2O)2POCH2-CO2CH3, K2CO3, 18-C-6, PhCH3–CH3CN, −15 °C (92%).
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