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. Author manuscript; available in PMC: 2008 Mar 1.
Published in final edited form as: Neuromuscul Disord. 2007 Feb 14;17(3):209–220. doi: 10.1016/j.nmd.2006.12.004

Figure 2.

Figure 2

Figure 2

Postnatal overexpression of CT carbohydrate in mdx skeletal muscle inhibits the development of muscle pathology but not muscle growth.

(A) AAV2-Galgt2 was used to overexpress CT carbohydrate in mdx muscle (tibialis anterior, infection at 2 weeks, staining at 6 weeks). Muscle was stained with DBA to identify CT carbohydrate overexpressing myofibers (left) and with hematoxylin and eosin on the next section in a serial series to determine myofibers with central nuclei. Myofibers overexpressing CT carbohydrate were protected from developing central nuclei. (B) Gastrocnemius muscle in an mdx mouse was infected with AAV1-Galgt2 at 2 weeks of age and analyzed for CT carbohydrate overexpression (green) and for central nuclei (red) at 6 weeks of age. Myofibers overexpressing CT carbohydrate were protected from muscle damage and did not contain central nuclei. Bar is 50μm in A and B.