Skip to main content
. Author manuscript; available in PMC: 2008 Mar 1.
Published in final edited form as: Neuromuscul Disord. 2007 Feb 14;17(3):209–220. doi: 10.1016/j.nmd.2006.12.004

Figure 6.

Figure 6

Postnatal overexpression of Galgt2 inhibits muscular dystrophy in mdx mice lacking utrophin.

Mdx mice lacking utrophin (mdxutrn-/-) or expressing utrophin (mdxutrn+/-) were infected with AAV1-Galgt2 or AAV8-like (rh.74) Galgt2 at 4 days to 1 week of age and analyzed at 6 weeks of age. Infected muscles were stained with antibody to the CT carbohydrate (CT2) in the fluorescein channel (green) and with a non-specific antibody to mark central nuclei in the rhodamine channel (red). Mdx myofibers overexpressing the CT carbohydrate did not have central nuclei, regardless of utrophin expression. Bar is 50μm.