TABLE 1. Changes in baseline latencies following chronic morphine administration.
Baseline latencies (± S.E.M.) are listed for each strain, treatment condition, and nociceptive assay following one of two published morphine regimens (Bryant et al. 2006; Kest et al. 2002). "B6" = C57BL/6J.
| Strain | Regimen | Treatment | Assay | Latency |
|---|---|---|---|---|
| 129S6 | Bryant | saline
morphine |
HP | 16.7±1.6
22.0±1.7* |
| 129S6 | Bryant | saline
morphine |
TW | 3.3±0.4
3.9±0.2 |
| 129P3 | Bryant | saline
morphine |
HP | 17.6±1.1
16.7±1.3 |
| 129P3 | Bryant | saline
morphine |
TW | 3.5±0.2
3.1±0.5 |
| 129P3 | Kest | day 1
day 4 |
TW | 2.9±0.2
2.7±0.3 |
| 129P3 | Kest | saline
morphine |
TW | 2.9±0.2
2.5±0.2 |
| B6 | Kest | day 1
day4 |
TW | 2.1±0.2
1.7±0.2* |
| B6 | Kest | saline
morphine |
TW | 2.3±0.2
1.5±0.08* |
| 129S6 | Bryant | saline
morphine MK+mor MK-801 |
HP | 14.9±1.6
16.1±1.1 20±1.2* 17.7±1.3 |
| CD-1 | Bryant | saline
morphine MK+mor MK-801 |
HP | 16.3±1.7
16.0±1.1 23.4±2.7* 25.7±1.9* |
*
significantly different from control mice receiving chronic saline or from day 1. A p-value of 0.05 was considered significant.