Table 1.
Effect of tuberculosis (TB) plasma on PPD-induced monokine secretion
| Stimulant | TNF-α† | (P)* | IL-6† | (P)* | IL-10† | (P)* |
|---|---|---|---|---|---|---|
| Spontaneous | ||||||
| PPD (10 μg/ml) | 46 ± 28 | 6 ± 4 | 1 ± 0 | |||
| + Ctrl plasma | 2274 ± 652 | 1592 ± 590 | 584 ± 371 | |||
| + TB plasma | 2380 ± 768 | 1587 ± 504 | 672 ± 162 | |||
| TB05 | 2118 ± 715 | (0·4) | 1859 ± 722 | (0·11) | 737 ± 103 | (0·46) |
| TB09 | 2148 ± 528 | (0·6) | 1747 ± 629 | (0·17) | 698 ± 75 | (0·46) |
| TB55 | 2337 ± 545 | (0·6) | 1926 ± 667 | (0·046) | 787 ± 124 | (0·46) |
| TB90 | 2354 ± 534 | (0·4) | 2222 ± 1045 | (0·116) | 991 ± 135 | (0·917) |
| TB149 | 5129 ± 1044 | (0·006) | 2828 ± 1602 | (0·028) | 826 ± 193 | (0·173) |
| TB153 | 5086 ± 1410 | (0·007) | 2213 ± 1103 | (0·463) | 672 ± 179 | (0·463) |
| TB157 | 4352 ± 1305 | (0·007) | 2405 ± 1260 | (0·173) | 966 ± 179 | (0·046) |
| TB167 | 4107 ± 949 | (0·037) | 2555 ± 1409 | (0·043) | 1012 ± 118 | (0·028) |
| P versus PPD alone | 0·032 | 0·001 | 0·001 | |||
†
n = 6. All values are given as pg/ml (mean ± s.e.m.).
*
Significance was determined by paired t-test in PPD-stimulated monocytes in the presence of control plasma versus TB plasma.