Table 4.
Effects of rolipram on the release of elastase from N-formyl-l-methionyl-l-leucyl-l-phenylalanine (FMLP)/CB-activated control and chronic granulomatous disease (CGD) neutrophils
| Release of elastase from FMLP/CB activated neutrophils | ||
|---|---|---|
| Without rolipram | With rolipram (1 μm) | |
| Control neutrophils (n = 3) | 269 ± 57 | 134 ± 26* |
| CGD neutrophils (n = 4) | 707 ± 49 | 88 ± 1** |
The results are expressed as the mean values ± s.e.m. in milliunits enzyme/107 cells and the assay was performed in triplicate for each subject. The values for unstimulated neutrophils from control and CGD subjects were 39 ± 4 and 41 ± 5 mU enzyme/107 cells, respectively.
*
P < 0·002
**
P < 0·0002.