Fig. 5.

Cutaneous DTH reactions were induced by intradermal injection in mice pre-immunized with methylated bovine serum albumin (mBSA). Control ice received isotype control IgG and/or vehicle (ethanol). Reactions were measured by callipers and expressed as the mean (± s.e.m.) difference between saline- and mBSA-injected sites in the same animals, in mm. Compared with control IgG, anti-MIF MoAb (15–30 mg/kg) (*P = 0·054, †P < 0·005) dose-dependently inhibited cutaneous DTH. Compared with vehicle, dexamethasone 0·2 mg/kg (DEX) also significantly inhibited DTH (‡P < 0·05). rMIF had no significant effect on the inhibition of DTH by DEX. In each case, n refers to the numbers of animals studied.