Table 1.
Humoral immunity and lymphocyte phenotype in the AT patients*
| Patient 1 | Patient 2 | Patient 3 | Reference values | |
|---|---|---|---|---|
| Humoral immunity (expressed as mg/dl) | ||||
| IgA | 159/167/126 | 65/–/119 | < 7/ < 7/ < 7 | 57–204 |
| IgM | 140/169/120 | 258/–/334 | 577/627/456 | 44–242 |
| IgG2 | –/86/77 | < 68/–/158 | 72/363/308 | 113–480 |
| PBMCs phenotype (expressed as percentage of positive cells) | ||||
| Lymphocytes | ||||
| (absolute number/µl) | 1711/940/844 | 1489/893/1845 | 2200/1650/1907 | 1652–4049 |
| T cells | ||||
| CD28 | 36/–/31 | 26/33/26 | 37/36/44 | 40–65 |
| CD3 | 54/55/48 | 40/54/42 | 48/57/60 | 59–77 |
| CD4 | 22/26/23 | 15/18/15 | 29/25/32 | 29–49 |
| CD4 naive | 2/–/2 | 4/2/2 | 3/1/4 | 16–39 |
| CD4 memory | 19/–/20 | 13/14/12 | 26/22/31 | 5–15 |
| CD8 | 22/18/17 | 25/34/25 | 16/21/16 | 11–37 |
| TcRαβ | –/47/25 | –/45/– | –/–/– | 55–70 |
| TcRγδ | 16/12/11 | 1/4/2 | –/5/2 | 2–7 |
| B cells | ||||
| CD19 | 9/8/7 | 6/5/3 | 38/31/28 | 8–23 |
| NK cells | ||||
| CD16 | 28/34/39 | 45/34/48 | 8/12/8 | 3–18 |
*
The following parameters were unaltered in the patients compared to controls: IgG, IgG1, IgG3, IgG4, C3, C4 and CH100 peripheral blood concentrations or activity. CD2, CD18, CD43, CD5, CD7, CD57, and CD14 PBMCs subpopulations. Reference values were obtained from 100 unrelated healthy children under 14 years. –, Not determined. Bars separate results obtained in different studies.