Table 3.
T-helper cell responses to HIV and other stimuli in cord blood from infants of HIV-seronegative women and HIV-seropositive women treated or untreated with short course zidovudine-lamivudine to prevent transmission
| N (%) infants with positive T-helper cell responses to each stimulus in cord blood | ||||
|---|---|---|---|---|
| HIV-seropositive women | ||||
| Stimulus* | HIV-seronegative women (n = 23) | Anti-retroviral treatment (n = 41) | No treatment (n = 29) | P-value† |
| HIV peptides | 0 (00·0) | 1 (2·4) | 7 (24·1) | 0·007 |
| PHA | 23 (100·0) | 39 (95·1) | 28 (96·6) | > 0·99 |
| ALLO | 10 (50·0)‡ | 21 (51·2) | 18 (62·1) | 0·466 |
| ALLO-NWD | 7 (35·0)‡ | 16 (39·0) | 11 (37·9) | > 0·99 |
| FLU | 0 (00·0) | 3 (7·3) | 6 (20·7) | 0·148 |
HIV peptides were a cocktail of synthetic envelope peptides (T1, T2, TH4·1, P18 MN, P18 IIIB). PHA (phytohemaglutinin) was used as mitogen, ALLO was a pool of undepleted leucocytes from 2 unrelated donors as stimulator cells, ALLO-NWD was a pool of leucocytes from 2 unrelated donors depleted of antigen presenting cells by nylon wool adherence as stimulator cells, and influenza A (FLU).
Two-tailed P-value from Fisher's exact test comparing treated and untreated groups.
Responses to ALLO and ALLO-NWD were measured only among 20 control samples.