Fig. 3.

The variability in LTB₄ release among skin tissues and the relation to the amount of tissue histamine, serum LTB₄ and total IgE levels of skin donors. The amounts of both constitutive and induced release of LTB₄ varied widely among the skin samples of 22 donors (a). The results of responders and nonresponders, defined in the results section are depicted by open and filled circles (a) or squares (b, c, d). The relationship between the amounts of histamine contained in tissues and the constitutive release of LTB₄ is shown in b. The correlation coefficient for all samples was 0·54 (P < 0·01) and is depicted by a solid line; that for responders was 0·67 (P < 0·025) and is depicted by a dotted line. No significant correlation was observed among spontaneous release of LTB₄, serum concentration of LTB₄, and total IgE levels in sera of the skin donors (c, d)