Fig. 4.

The effects of dexamethasone on the release of histamine and LTB₄ induced by SP. The human skin slices were treated with or without 1 µm dexamethasone for 16 h, followed by incubation in the presence or absence of 100 µm SP for 20 min. The amounts of histamine (a) and LTB₄ (b) released into the medium were measured as described in the materials and methods section and expressed as percent release of total histamine and ratio to spontaneous release of LTB₄ in each sample (1166·8, 2328·1, 7852·4 pg/g wet tissue), respectively. Data are expressed as means ±SEM of three independent experiments. *P < 0·05 (Student's t-test)