Fig. 2.
Effect of monoclonal antibodies against β2-glycoprotein I and cardiolipin (direct) on in-vitro thrombin generation. Two murine MoAbs were derived from the same host. The predominant reactivity of MoAb FC1 was directed against β2-glycoprotein I and inhibited in vitro thrombin generation by 49% at a concentration of 75 µg/ml. In contrast the predominant reactivity of MoAb FC3 was against cardiolipin and had a negligible impact on in-vitro thrombin generation at the same antibody concentration. ○, Spontaneous; ▪, FC1; □, FC3.