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Cytokine production of spleen adherent cells stimulated with SAC. a, IL-1α; b, IL-6; c, IL-12 p70. Spleen adherent cells (1 × 106/ml) from control and phenytoin-treated mice were cultured with 0·005% SAC for 18 h and culture supernatants were harvested. Cytokines were detected by ELISA. Results are expressed as mean ± SE of cytokines (pg/ml) produced by 106 spleen adherent cells (n = 6). * significantly different.
