Table 3.
Serum CD26 (DPPIV) enzyme activity and CMV antigen-induced IFN-γ production in CMV-seropositive subjects stratified by high and low serum sCD30 levels
| n | sCD30 sub groups* | sCD30 (u/ml) | CD4+ T cells (cells/µl) | CD26 (DPPIV) enzyme activity (u/ml) | IFN-γ in cell culture supernatant (U/ml) | IFN-γ ELISpots (per 2 × 105 cells) | |
|---|---|---|---|---|---|---|---|
| Controls | 7 | H | 209(123–323)† | N/A | 280(147–572) | 0·5(0·23–2·1)‡ | 56 (14–84)§ |
| 5 | L | 31(14–101) | N/A | 203(136–275) | 5·6 (4·9–39) | 198 (100–400) | |
| Group 1 | 14 | H | 305(183–7097) | 321(60–700) | 322(153–1344) | 0·3(0·1–4·8) | 19(0–183) |
| 15 | L | 53(30–130) | 270(60–1107) | 254(125–594) | 0·7(0·1–15) | 52(1–315) | |
| Group 2 | 4 | H | 141(105–3527) | 23(5–45) | 190(177–221) | 0·3(0·11–4) | 0(0) |
| 3 | L | 69(27–81) | 12(3–18) | 118(89–302) | 0·1(0·1–0·25) | 1(0–3) |
*
H = high sCD30 (equal to or greater than median value), L = low sCD30 (lower than median value).
†
= median (range).
‡
Significantly lower than controls with high sCD30 levels (P = 0·0043).
§
Significantly lower than controls with high sCD30 levels (P = 0·009).