Table 1.
Virus titre in nasal wash * | ||||
---|---|---|---|---|
Immunization status | No. of mice (each strain) | Day of sacrifice post-challenge | C3HeB | BALB/c |
Immunized | 8 | 2 | 2·4 ± 1·5‡ | 3·3 ± 1·5‡ |
Immunized | 8 | 4 | 2·2 ± 1·0‡ | 2·8 ± 0·7‡ |
Non-immune | 8 | 2 | 3·6 ± 0·5§ | 5·1 ± 0·2 |
Non-immune | 8 | 4 | 3·4 ± 0·4§ | 4·7 ± 0·4 |
Data are mean log pfu/ml lavage ± SD; no virus (i.e. titre < 1·4 in our assay) was detected in immunized (n = 8 per strain) or non-immune (n = 6 per strain) mice challenged with inactivated virus, or not challenged with intranasal virus.
Different (F = 10·4, all t ≥ 2·2, all P < 0·05) from syngeneic nonimmune mice challenged with infectious virus and sacrificed on the same day post-challenge.
Different (all t ≥ 3·4, all P < 0·01) from the same treatment group in the BALB/c strain.