Table 1.
Effect of 1,25(OH)2D3 on the growth of normal and malignant lymphoid progenitors
| Progenitor cells | Sample | Source of stimulation | Colonies/105 cells Mean (s.d.) |
|---|---|---|---|
| B-lineage | PB | None | 0 (0) |
| PHA-TCM | 54 (15.8) | ||
| 1,25(OH)2D3 | 0 (0) | ||
| 1,25(OH)2D3 + PHA-TCM | 12.7 (6.97) | ||
| T-lineage | PB | None | 0 (0) |
| PHA-LCM | 64.6 (30.1) | ||
| 1,25(OH)2D3 | 0 (0) | ||
| 1,25(OH)2D3 + PHA-TCM | 23.2 (7.89) | ||
| B-lineage ALL | BM | None | 2.1 (1) |
| PHA-TCM | 50 (8.5) | ||
| 1,25(OH)2D3 | 8.3 (3.5) | ||
| 1,25(OH)2D3 + PHA-TCM | 11.7 (3.1) |
PB: peripheral blood; BM: bone marrow; PHA-LCM: PHA-leucocyte conditioned medium; PHA-TCM: PHA-T lymphocytes conditioned medium.