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Approaches to eliminating graft reactive lymphocytes. a, The staurosporine analogues Bis III and VIII increase the sensitivity of activated T cells to caspase-dependent Fas-mediated apoptosis. b, Elimination of alloreactive lymphocytes via Fas-mediated cell death. Graft cells or activated T cells, which either naturally express FasL or are genetically engineered to express FasL, can engage Fas on alloreactive T cells and trigger caspase-dependent apoptosis.
