Table 2.
Peak Stimulation Index (SI) values to MBP and MBP-peptides in MS patients obtained at three separate time points (see Materials and Methods)
| Time point | MBP | 1–24 | 15–39 | 30–54 | 45–69 | 60–84 | 75–99 | 90–114 | 105–129 | 120–144 | 135–159 | 150–170 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MS10 | 1 | 14 | 17 | 3 | 15 | 55 | 1 | 1 | 2 | 15 | 1 | 2 | 1 |
| 2 | 4 | 1 | <1 | <1 | <1 | <1 | 9 | 4 | 1 | <1 | 4 | 1 | |
| 3 | 8 | 3 | 1 | 1 | 1 | <1 | 1 | 1 | 2 | 1 | 1 | 0 | |
| MS17 | 1 | 29 | 1 | 1 | 1 | 1·5 | 2 | 1 | <1 | 1 | 1 | 1·5 | 2 |
| 2 | 51 | 1 | <1 | 1 | <1 | <1 | <1 | <1 | <1 | <1 | 1 | 5 | |
| 3 | 51 | 1 | <1 | 2 | 1 | 1 | <1 | 2 | 1 | 1 | 1 | 1 | |
| MS19 | 1 | 1 | 2 | 1 | <1 | <1 | <1 | 1 | <1 | <1 | <1 | <1 | <1 |
| 2 | 1·5 | <1 | <1 | <1 | <1 | <1 | <1 | <1 | <1 | <1 | <1 | <1 | |
| MS39 | 1 | 39 | 3 | 5 | 1 | 3 | 2 | 2 | 7·5 | 6 | <1 | 2 | 2 |
| 2 | 58 | 1 | <1 | <1 | 2 | 2 | <1 | <1 | <1 | 1 | <1 | <1 | |
| 3 | 50 | 8 | 1 | 1 | 1 | 2 | 1 | 1·5 | 1 | <1 | 3 | <1 | |
| MS41 | 1 | 59 | 2 | 3 | 2 | 2 | 1·5 | 1 | 1 | 2 | 6 | 7 | 3 |
| 2 | 116 | <1 | 1 | <1 | <1 | <1 | 1 | <1 | 1 | <1 | <1 | <1 | |
| 3 | 74 | 2 | 1·5 | 1 | 2 | 2 | 8 | <1 | <1 | <1 | 95 | <1 | |
| MS43 | 1 | 32 | 4 | 22 | 3 | 3 | 3 | 24 | 4 | 2 | 12 | 3 | 4 |
| 2 | 75 | <1 | <1 | <1 | <1 | <1 | <1 | <1 | <1 | <1 | <1 | <1 | |
| 3 | 66 | 2 | 2 | 1 | 13 | 2 | 1 | 2 | 2 | 2 | 7 | 1 | |
| MS49 | 1 | 6 | 5 | 9 | 11 | 5 | 4 | 11 | 4 | 35 | 6 | 5 | 31 |
| 2 | 202 | 2 | 8 | 23 | 4 | 3 | 2 | 73 | 2 | 2 | 11 | 34 | |
| 3 | 6 | 13 | 8 | 17 | 1 | 1 | 11 | 11 | 4 | 1 | 7 | 6 | |
| MS57 | 1 | 36 | 8 | <1 | 1·5 | 1 | 1 | 2 | 2 | <1 | <1 | <1 | <1 |
| 2 | 7 | 2 | 2 | 2 | 1 | 1 | <1 | <1 | <1 | <1 | <1 | <1 | |
| 3 | 6 | <1 | <1 | <1 | <1 | <1 | <1 | <1 | <1 | <1 | <1 | <1 | |
| MS59 | 1 | 57 | 2 | 1 | 65 | 1 | 1 | 9 | 37 | 1 | 1 | 2 | 14 |
| 2 | 27 | 1 | <1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |
| 3 | 14 | 1 | 9 | 2 | 1 | 1 | 4 | 2 | 2 | 63 | 137 | 1 | |
| MS60 | 1 | 44 | 3 | 2 | 19 | 8 | 2 | 28 | 9 | 11 | 16 | 16 | 12 |
| 2 | 133 | 1 | <1 | 83 | <1 | <1 | 20 | <1 | 1 | <1 | 2 | <1 | |
| 3 | 23 | 2 | <1 | 13 | <1 | 2 | <1 | <1 | <1 | 10 | 26 | 2 | |
| MS67 | 1 | 49 | 2 | 3 | 2 | 1 | 2 | 2 | 1 | <1 | 1 | 1 | 58 |
The SI values shown here are derived from the day on which the T-cell response peaked. Background cpm was measured for each day and varied between 80 and 700cpm; a positive response (bold) was defined according to SI > 3 and δcpm > 1000. All patients, including MS19, gave a positive response to PPD at each time point (data not shown). It was not possible to collect samples for a third time point from patients MS19 and MS67.