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Modulation of intracellular IL-1ra (a), IL-1α (b) and IL-1ra : IL-1α ratio (c) by cytokines in oral mucosal cells. Cells were incubated for 24 h with RPMI 1640 alone as control (C), IFN-γ, IL-10, TGFβ1, IL-4, TNFα, IL-6 or hydrocortisone (HC). The concentration of cytokines in culture lysates was determined by ELISA. The results represent the mean of two experiments, each performed from different cultures. P < 0·05.
