Fig. 4.
Anti-rat Ig responses in anti-B7-1 or anti-B7-2 treated mice. Groups of five mice were treated as described in protocol 1. Week 2 sera were evaluated for the presence of antibodies to rat Ig by ELISA as described in the Materials and methods section and results are expressed in absorbances ± s.d. Only animals receiving single anti-B7-1 or anti-B7-2 MoAbs developed mouse antirat Ig responses. Absorbances in mice treated with both anti-B7-1 and anti-B7-2 MoAbs or in mice receiving HgCl2 without rat MoAb treatment were similar to those of animals receiving no treatment at all.