Table 1.
Total cell count, granulocytes, epithelial and lymphoid cells before and after nasal challenge with gliadin and albumin in coeliac patients and controls
| Coeliacs (n = 21) | Controls (n = 12) | |||
|---|---|---|---|---|
| Gliadin | Albumin | Gliadin | Albumin | |
| Cells | 40·5 (29–56·6)* | 43·1 (29·6–62·6) | 36·2 (24–54·6) | 56·1 (41·3–76·3) |
| Time 0 (cell/mm3) | ||||
| Cells | 74·2 (51·5–106·9) | 41·8 (27·7–63·1) | 42·8 (24·5–75·1) | 51·8 (27·4–79·9) |
| Time 6 h (cell/mm3) | t = 2·73* | t < 0·1 | t < 0·1 | t < 0·1 |
| P = 0·014 | P > 0·05 | P > 0·05 | P > 0·05 | |
| Granulocytes | 19·7 (11·1–28·3) | 30 (17·4–42·6) | 21·7 (12·4–30·9) | 20·2 (9·2–31·2) |
| Time 0 (%) | ||||
| Granulocytes | 30 (18–42) | 36·3 (22·9–49·7) | 25·2 (13·3–37·1) | 30 (14·5–45·4) |
| Time 6 h (%) | t = 1·75 | t < 0·1 | t < 0·1 | t < 0·1 |
| P = 0·097 | P > 0·05 | P > 0·05 | P > 0·05 | |
| Epithelial cells | 54·5 (44·2–64·8) | 47·6 (33·8–61·3) | 49 (37–60·9) | 47·4 (37·3–57·4) |
| Time 0 (%) | ||||
| Epithelial cells | 27·3 (19–35·5) | 35 (22·8–47·2) | 37·9 (26·7–49) | 39 (24·6–53·3) |
| Time 6 h (%) | t = 4·86 | t < 0·1 | t < 0·1 | t < 0·1 |
| P = 0·0001 | P > 0·05 | P = 0·032 | P > 0·05 | |
| Lymphoid cells | 25·7 (16·6–34·7) | 23 (15·7–32·3) | 30 (21·9–38) | 32·2 (23·3–40·8) |
| Time 0 (%) | ||||
| Lymphoid cells | 42 (30·6–53·3) | 29 (19·7–38·3) | 37·4 (23·8–50·9) | 31 (17·5–44·5) |
| Time 6 h (%) | t = 2·98 | t < 0·1 | t < 0·1 | t < 0·1 |
| P = 0·008 | P > 0·05 | P > 0·05 | P > 0·05 | |
*
Mean and 95% confidence intervals. Paired Student’s t-test was used to compare time 0 values with post-challenge values (6 h).