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The effect of a second in vitro LPS challenge on percentage of monocytes producing IL-1β, TNFα or IL-12, before, and 3, 6 and 24 h following LPS injection in the two control individuals not treated with RWJ-67657. Results are expressed relative to the value before injection of LPS (t = 0). Each line represents an individual, open symbols for one individual, closed symbols for the other individual. (□,▪) IL-1β; (○,•) TNFα; (▵,▴) IL-12.
