Table 2.

Treatment of children with immunosuppressive drugs and formation of autoantibodies against cytochrome P450s

					Serum transaminases
	Age at onset of treatment (year)		Duration of treatment (year)		Pos. population			Total population
	Pos. pop.	Total pop.	Pos. pop.	Total pop.	ALAT (U/l)	ASAT (U/l)	γGT (μkat/l)	ALAT (U/l)	ASAT (U/l)	(GT (μkat/l)
Kidney transplant	*5 ± 4	8 ± 5	4 ± 3	4 ± 3	720	800	1·6	230	400	0·24
					70–2480	270–1980	0·18–10	60–2820	180–1280	0·15–9·6
Nephrotic/kidney transplant	1·3 ± 0·5	9 ± 5	4·5 ± 2	5 ± 3
Nephrotic/	2	6 ± 3	5·5	3 ± 2
Liver disease transplant	3·8 ± 1·3	8·6 ± 7	1 ± 0	3·7 ± 2·5
Total	4·5 ± 3·5	7·6 ± 6	4 ± 2·7	4 ± 3·2

The data shown were obtained from the children described in Table 1. Total = total patient population for which data were available. Age at onset of drug treatments between the patients of positive sera reactivity and the total patient population is statistically significant at

^*P = 0·1, Student’s unpaired t-test. The values of laboratory tests for serum transaminase are given as the mean and range. NA, Values not available.