Fig. 2.

(a) Basal and (b) LPS-stimulated (20 h) cytoplasmic IL-12 expression in active, generalized WG patients and healthy controls. The number of IL-12 positive monocytes was significantly elevated compared with healthy controls without, but not with, LPS stimulation (P < 0·05 and P > 0·05, respectively). Two and 12 weeks of treatment with CYC and GC normalized the increased IL-12 expression. The percentages of IL-12-staining monocytes are indicated for individuals in each group and means are indicated by a horizontal line.