Fig. 1.

Analysis of glomerular hypercellularity and glomerular cell proliferation in control and IL-10 treated rats with mesangial proliferative GN. Dotted lines represent values for normal rats without GN. (a) Glomerular hypercellularity was reduced in rats with GN that were given IL-10 (IL-10 GN) compared with control treated rats (Ctrl GN). (b) The average numbers of cells per glomerular cross-section (c/gcs) positive for PCNA was reduced in IL-10 treated rats. (c) Cellular proliferation, as measured by the incorporation of BrdU into cells undergoing DNA synthesis, was reduced in rats with GN that had received IL-10. *P < 0·05 versus control rats with GN.