Table 1.

Effect of C-ANCA-positive IgG fraction from patients with active Wegener's granulo-matosis on pulmonary tissue of rats

		Pulmonary vasculitis
C-ANCA IgG from patient	No. of animals injected	Pos (%)	Intensity of inflammatory response*(n)	Granuloma-like formation Pos (%)
1	3	3(100)	2+(3)	0
2	7	7(100)	2+(4)	3(43)
			3+(3)
3	8	8(100)	2+(4)	4(50)
			3+(4)

Rats were injected via intrajugular vein with a single dose of 20mg of human C-ANCA-positive IgG fraction. Lungs were removed 24h later for histological analysis.

^*Inflammatory infiltrate score: (−) absent; (1+) scarce; (2+) moderate; (3+) intense.