Table 2.
Effect of control human IgG fractions on pulmonary tissue of rats
| Pulmonary vasculitis | ||||
|---|---|---|---|---|
| Control IgG | No.of animals injected | Pos (%) | Intensity of inflammatory response* (n) | Granuloma-like formation Pos (%) |
| NL 1 | 4 | 1(25) | −(3) | 0(0) |
| 2+(1) | ||||
| NL 2 | 3 | 0(0) | − | 0(0) |
| NL 3 | 3 | 0(0) | − | 0(0) |
| NL 4 | 5 | 0 (0) | − | 0(0) |
| RA 1 | 6 | 0(0) | − | 0(0) |
| RA 2 | 1 | 0(0) | − | 0(0) |
Rats were injected via intrajugular vein with a single dose of 20mg of normal human IgG (NL) and rheumatoid arthritis IgG (RA). Lungs were removed 24h later for histological analysis.
*
Inflammatory infiltrate score: (−) absent; (1+) scarce; (2+) moderate; (3+) intense.