Table 3.

Dose–response effect of C-ANCA-positive IgG fraction from patient 3 on pulmonary tissue of rats

		Pulmonary vasculitis
Dose of IgG (mg of protein)	No.of animals injected	Pos(%)	Intensity of inflammatory response * (n)	Granuloma-like formation Pos (%)
6	4	1(25)	2+(1)	0(0)
12	2	2(100)	2+(2)	0(0)
20	8	8(100)	2+(4)	4(50)
			3+(3)

Groups of rats received via intrajugular vein a single dose of 6, 12 and 20 mg of C-ANCA-positive IgG fraction from WG patient 3. Lungs were removed 24 h later for histological examination.

^*Inflammatory infiltrate score: (−) absent; (1+) scarce; (2+) moderate; (3+) intense.