Fig. 1.

Weight loss is delayed when disease is induced by the transfer of CD4⁺ CD45RB^high T cells from β7 integrin −/− mice. Donor lymphocytes were prepared as described and injected into recipient animals. The results show the change in weight as a percentage of original weight at day 0, the time of injection. Each data point represents the mean and the standard error for the indicated number of mice in each group: recipients of wild-type cells (N = 5), recipients of β7 integrin −/− cells (N = 4). Statistical analysis was performed using Student's two-tailed t-test to compare the two groups at 7 weeks. * indicates P = 0·0004. ▪, β7 Integrin −/−; ▴, wild-type.