Fig. 2.

Delayed colonic inflammation following transfer of β7 −/− T cells. Colonic sections were obtained post mortem, fixed in formalin and stained with haematoxylin–eosin. Each panel is a representative section of the large intestine from animals in the following experimental groups. (a) Normal B6 SCID mouse without induced colitis. (b) Severe colonic inflammation at 9 weeks following transfer of wild-type CD4⁺ CD45RB^high T cells. (c) Absence of colonic inflammation at 9 weeks following transfer of CD4⁺ CD45RB^high T cells from β7 integrin −/− mice. (d) Severe colonic inflammation at 25 weeks following transfer of CD4⁺ CD45RB^high T cells from β7 integrin −/− mice (magnification 40×).