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. 2002 Aug;129(2):232–239. doi: 10.1046/j.1365-2249.2002.01922.x

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© 2002 Blackwell Science Ltd

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Fig. 2 — Metallothionein reduced histopathological manifestations of CIA. On day 34 postimmunization, mice (n = 15 per group) were sacrificed and right hindpaws were removed. The specimens were fixed, decalcified, embedded in paraffin, sectioned, and stained with haematoxylin and eosin. (a) Joints of normal mice; (b) mainly normal joints from metallothionein-treated mice; (c) moderately arthritic joints from metallothionein-treated mice; (d) severely arthritic joints from vehicle-treated mice. Original magnification: ×40. Percentage of histological score per group is shown in (e). □ Normal; moderate; ▪ severe.

Inline graphic — Metallothionein reduced histopathological manifestations of CIA. On day 34 postimmunization, mice (n = 15 per group) were sacrificed and right hindpaws were removed. The specimens were fixed, decalcified, embedded in paraffin, sectioned, and stained with haematoxylin and eosin. (a) Joints of normal mice; (b) mainly normal joints from metallothionein-treated mice; (c) moderately arthritic joints from metallothionein-treated mice; (d) severely arthritic joints from vehicle-treated mice. Original magnification: ×40. Percentage of histological score per group is shown in (e). □ Normal; moderate; ▪ severe.