Fig. 2.

Inhibition of cytokine production from FLS by troglitazone. FLS (samples from six RA patients) were cultured with or without troglitazone (1 or 10 μm) for 72 h, and the protein concentrations of (a) IL-6, (b) IL-8 and (c) TNF-α in the cultured supernatants were examined by ELISA, respectively. Data are mean ± s.d. concentrations relative to the corresponding values in unstimulated FLS from six RA samples. Note that the production of IL-6 and IL-8 from FLS was dose-dependently suppressed by troglitazone, and that the TNF-α concentrations in the FLS culture media decreased to undetectable levels in the presence of troglitazone. * P <0·01 ( Student's t-test).