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. 2002 Sep;129(3):429–437. doi: 10.1046/j.1365-2249.2002.01934.x

Table 2.

Binding capacities of Nef 56–68 peptide to HLA class II molecules

Alleles Allelic frequencies (%) Referenced peptide Referenced peptide IC50 (nM) Nef 56–68 peptide IC50 (nM) Ratio Binding
DQ2 DQA1*0201/DQB1*0201 12·4/23·1 MHC I α46–63 620 (±150) 1100 (±188) 1·8 +
DQ2 DQA1*0501/DQB1*0201 27·4/23·1 MHC I α46–63 340 (±160) 180 (±30) 0·5 +*Τ*+
DQ7 DQA1*0501/DQB1*0301 27·4/18·5 DQB45–57 60 (±20) 31000 (±18000) 517
DQ8 DQA1*0301/DQB1*0302 14·2/8·1 DQB45–57 1150 (±350) 44 (±9) 0·04 +*Τ*+
DQ5 DQA1*0101/DQB1*0505 17/14·9 Ig44–60 620 (±150) 3500 (±1800) 5·6 +
DQ6 DQA1*0102/DQB1*0602 15·8/9·8 INS1–15A 170 (±35) 3100 (±760) 18 +
DQ6 DQA1*0103/DQB1*0603 6·2/5·8 B7150–164 2200 (±760) 24000 (±8660)  11 +
DR1 DRB1*0101 9·3 HA306–318[20] 6 (±1) >10000 >1666
DR3 DRB1*0301 10·9 MT2–16[20] 120 (±40) >10000  >84
DR4 DRB1*0401 5·6 HA306–318[20] 30 (±30) >10000 >333
DR7 DRB1*0701 14·0 YKL [20] 130 (±40) >10000 >77
DR11 DRB1*1101 9·2 HA306–318[20] 20 (±4) 2200 (±*Τ*350) 110
DR13 DRB1*1301 6·0 B121–36[20] 1000 (±0) >100000 >100
DR15 DRB1*1501 8·0 A3152–166[20] 30 (±17) >10000 >333
DR51 DRB5*0101 7·9 HA306–318[20] 10 (±0) >10000 >1000
DR52 DRB3*0101 9·2 14·166 [20] 10 (±0) >10000 >1000
DR53 DRB4*0101 28·4 E2/E7 [20] 4 (±1) >10000 >2500