Table 2.
Binding capacities of Nef 56–68 peptide to HLA class II molecules
| Alleles | Allelic frequencies (%) | Referenced peptide | Referenced peptide IC50 (nM) | Nef 56–68 peptide IC50 (nM) | Ratio | Binding | |
|---|---|---|---|---|---|---|---|
| DQ2 | DQA1*0201/DQB1*0201 | 12·4/23·1 | MHC I α46–63 | 620 (±150) | 1100 (±188) | 1·8 | + |
| DQ2 | DQA1*0501/DQB1*0201 | 27·4/23·1 | MHC I α46–63 | 340 (±160) | 180 (±30) | 0·5 | +*Τ*+ |
| DQ7 | DQA1*0501/DQB1*0301 | 27·4/18·5 | DQB45–57 | 60 (±20) | 31000 (±18000) | 517 | − |
| DQ8 | DQA1*0301/DQB1*0302 | 14·2/8·1 | DQB45–57 | 1150 (±350) | 44 (±9) | 0·04 | +*Τ*+ |
| DQ5 | DQA1*0101/DQB1*0505 | 17/14·9 | Ig44–60 | 620 (±150) | 3500 (±1800) | 5·6 | + |
| DQ6 | DQA1*0102/DQB1*0602 | 15·8/9·8 | INS1–15A | 170 (±35) | 3100 (±760) | 18 | + |
| DQ6 | DQA1*0103/DQB1*0603 | 6·2/5·8 | B7150–164 | 2200 (±760) | 24000 (±8660) | 11 | + |
| DR1 | DRB1*0101 | 9·3 | HA306–318[20] | 6 (±1) | >10000 | >1666 | − |
| DR3 | DRB1*0301 | 10·9 | MT2–16[20] | 120 (±40) | >10000 | >84 | − |
| DR4 | DRB1*0401 | 5·6 | HA306–318[20] | 30 (±30) | >10000 | >333 | − |
| DR7 | DRB1*0701 | 14·0 | YKL [20] | 130 (±40) | >10000 | >77 | − |
| DR11 | DRB1*1101 | 9·2 | HA306–318[20] | 20 (±4) | 2200 (±*Τ*350) | 110 | − |
| DR13 | DRB1*1301 | 6·0 | B121–36[20] | 1000 (±0) | >100000 | >100 | − |
| DR15 | DRB1*1501 | 8·0 | A3152–166[20] | 30 (±17) | >10000 | >333 | − |
| DR51 | DRB5*0101 | 7·9 | HA306–318[20] | 10 (±0) | >10000 | >1000 | − |
| DR52 | DRB3*0101 | 9·2 | 14·166 [20] | 10 (±0) | >10000 | >1000 | − |
| DR53 | DRB4*0101 | 28·4 | E2/E7 [20] | 4 (±1) | >10000 | >2500 | − |