Table 3.

Intracerebral parasite load in SCID mice humanized with PBMC from H IV-infected patients during HAART

Animal group	Number of cysts*	Number of tachyzoite foci (mean ± SEM)†
D0	+ + + +	105 ± 15
M6	+	5 ± 2*
M12	+ + to + + +	77 ± 11**
PBMC Toxo +	+ +	8 ± 1*
PBMC Toxo −	+ + +	100 ± 21**

^*The number of Toxoplasma cysts was determined on 400 high-power fields/section. A semiquantitative grading system was used to evaluate the number of cysts (+ 1–5 cysts; + + 5–10 cysts; + + + 10–20 cysts; + + + + more than 20). A total of 10–15 sections from various regions of the brain were counted, and data are expressed as the mean number of cysts/section for four mice per group.

^†The number of foci of Toxoplasma tachyzoites was determined on 400 high-power fields/section. A total of 10–15 sections from various regions of the brain were counted, and data are expressed as the mean (± SEM) number of tachyzoites/section for four mice per group. Differences between groups of animals in the mean number of tachyzoites were compared by Wilcoxon's test.

^*P < 0·05 versus D0

^**P < 0·05 versus M6