Fig. 5.
Effect of MoAb 3B9 on the production of IgE from SCID mice reconstituted with immune cells from atopic volunteers. Six−8-week-old SCID mice received purified PBMCs from house dust mite-sensitive donors, dosed with rhIL-4 for 4 days and a single IP MoAb 3B9 injection at the time of PBMC administration. ▴, IL-4; ▪, IL-4 + MoAb 3B9 (0·5 mg); , IL-4 + MoAb 3B9 (1.0 mg); •, IL-4 + 3B9 (10 mg).