Table 5.
Observed (Obs) and expected (Exp) numbers and standardized incidence ratios (SIRs) of cancer among relatives of patients with IgA deficiency or CVID in Denmark and Sweden
| All malignant neoplasms | Stomach cancer | Lymphomas | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Subgroup of relatives | No | Obs | Exp | SIR | 95% CI | Obs | Exp | SIR | 95% CI | Obs | Exp | SIR | 95% CI |
| All | 2071 | 219 | 194·4 | 1·1 | 1·0–1·3 | 5 | 8·0 | 0·6 | 0·2–1·5 | 8 | 6·9 | 1·2 | 0·5–2·3 |
| Familial relationship | |||||||||||||
| Parents | 920 | 134 | 127·5 | 1·1 | 0·9–1·3 | 0 | 5·2 | – | 0·0–0·7 | 3 | 4·3 | 0·7 | 0·1–2·0 |
| Siblings | 805 | 10 | 10·2 | 1·0 | 0·5–1·8 | 0 | 0·1 | – | 0·0–30·7 | 0 | 0·8 | – | 0·0–4·7 |
| Offspring1 | 93 | 0 | 0·6 | – | 0·0–6·5 | 0 | 0·0 | – | – | 0 | 0·1 | – | 0·0–61·5 |
| Grandparents2 | 253 | 75 | 56·2 | 1·3 | 1·0–1·7 | 5 | 2·7 | 1·9 | 0·6–4·4 | 5 | 1·8 | 2·8 | 0·9–6·6 |
| Type of immunodeficiency | |||||||||||||
| IgA deficiency | 1445 | 166 | 142·2 | 1·2 | 1·0–1·4 | 5 | 5·8 | 0·9 | 0·3–2·0 | 5 | 5·1 | 1·0 | 0·3–2·3 |
| CVID | 626 | 53 | 52·2 | 1·0 | 0·8–1·3 | 0 | 2·0 | – | 0·0–1·8 | 3 | 1·8 | 1·6 | 0·3–4·8 |
| Country | |||||||||||||
| Denmark | 505 | 13 | 17·8 | 0·7 | 0·4–1·3 | 0 | 0·3 | – | 0·0–11·5 | 1 | 0·7 | 1·4 | 0·0–8·0 |
| Sweden | 1566 | 206 | 176·6 | 1·2 | 1·0–1·3 | 5 | 7·6 | 0·7 | 0·2–1·5 | 7 | 6·2 | 1·1 | 0·5–2·3 |
CVID, common variable immunodeficiency.
1
Only identified in Denmark.
2
Only identified in Sweden.