Table 3.
48 genes overexpressed in hESCs compared to differentiated cell types in at least 10 studies
| Abbreviation | Name | Chr.£ | Unigene | Nb of studies | Ratio Und/Dif Signal§ |
|---|---|---|---|---|---|
| POU5F1 | POU domain, class 5, transcription factor 1 | 6p21.31 | Hs.249184 | 20 | 56.4 |
| TDGF1 | Teratocarcinoma-derived growth factor 1 | 3p21.31 | Hs.385870 | 17 | 55.0 |
| DPPA4 | Developmental pluripotency associated 4 | 3q13.13 | Hs.317659 | 16 | 30.1 |
| LIN28 | Lin-28 homolog (C. elegans) | 1p36.11 | Hs.86154 | 16 | 24.8 |
| NANOG | Nanog homeobox | 12p13.31 | Hs.329296 | 15 | 88.9 |
| DNMT3B | DNA (cytosine-5-)-methyltransferase 3 beta | 20q11.2 | Hs.251673 | 15 | 27.8 |
| TERF1 | Telomeric repeat binding factor (NIMA-interacting) 1 | 8q13 | Hs.442707 | 15 | 18.9 |
| SEMA6A | Semaphorin 6A | 5q23.1 | Hs.156967 | 15 | 12.3 |
| M6PR | Mannose-6-phosphate receptor (cation dependent) | 12p13 | Hs.134084 | 15 | 10.6 |
| SNRPN | Small nuclear ribonucleoprotein polypeptide N | 15q11.2 | Hs.525700 | 15 | 7.3 |
| FLJ10884 | Hypothetical protein FLJ10884 | 1p31.3 | Hs.562195 | 14 | 260.7 |
| LEFTY1 | Left-right determination factor 1 | 1q42.1 | Hs.278239 | 14 | 34.1 |
| GAL | Galanin | 11q13.2 | Hs.278959 | 14 | 21.4 |
| SEPHS1 | Selenophosphate synthetase 1 | 10p14 | Hs.124027 | 14 | 6.3 |
| GABRB3 | Gamma-aminobutyric acid (GABA) A receptor, beta 3 | 15q11.2-q1 | Hs.302352 | 13 | 15.3 |
| SOX2 | SRY (sex determining region Y)-box 2 | 3q26.3-q27 | Hs.518438 | 13 | 15.3 |
| LECT1 | Leukocyte cell derived chemotaxin 1 | 13q14-q21 | Hs.421391 | 12 | 37.2 |
| LOC90806 | Similar to RIKEN cDNA 2610307I21 | 1q32.3 | Hs.157078 | 12 | 14.6 |
| BUB1 | BUB1 budding uninhibited by benzimidazoles 1 homolog | 2q14 | Hs.469649 | 12 | 11.2 |
| PSIP1 | PC4 and SFRS1 interacting protein 1 | 9p22.3 | Hs.493516 | 12 | 5.4 |
| INDO | Indoleamine-pyrrole 2,3 dioxygenase | 8p12-p11 | Hs.840 | 11 | 34.4 |
| HELLS | Helicase, lymphoid-specific | 10q24.2 | Hs.546260 | 11 | 19.3 |
| GPC4 | Glypican 4 | Xq26.1 | Hs.58367 | 11 | 15.4 |
| ITGB1BP3 | Integrin beta 1 binding protein 3 | 19p13.3 | Hs.135458 | 11 | 15.3 |
| CYP26A1 | Cytochrome P450, family 26, subfamily A, polypeptide 1 | 10q23-q24 | Hs.150595 | 11 | 14.2 |
| MCM5 | MCM5 minichromosome maintenance deficient 5 | 22q13.1 | Hs.517582 | 11 | 11.9 |
| MTHFD1 | Methylenetetrahydrofolate dehydrogenase 1 | 14q24 | Hs.435974 | 11 | 8.7 |
| PPAT | Phosphoribosyl pyrophosphate amidotransferase | 4q12 | Hs.331420 | 11 | 8.3 |
| SLC16A1 | AKR7 family pseudogene | 1p12 | Hs.75231 | 11 | 7.8 |
| NASP | Nuclear autoantigenic sperm protein (histone-binding) | 1p34.1 | Hs.319334 | 11 | 7.4 |
| DLG7 | Discs, large homolog 7 (Drosophila) | 14q22.3 | Hs.77695 | 11 | 6.7 |
| UGP2 | UDP-glucose pyrophosphorylase 2 | 2p14-p13 | Hs.516217 | 11 | 6.1 |
| MSH2 | MutS homolog 2, colon cancer, nonpolyposis type 1 | 2p22-p21 | Hs.156519 | 11 | 3.4 |
| ZIC3 | Zic family member 3 heterotaxy 1 | Xq26.2 | Hs.111227 | 10 | 30.7 |
| PIM2 | Pim-2 oncogene | Xp11.23 | Hs.496096 | 10 | 18.5 |
| HRASLS3 | HRAS-like suppressor 3 | 11q12.3-q1 | Hs.502775 | 10 | 16.8 |
| ALPL | Alkaline phosphatase, liver/bone/kidney | 1p36.1-p34 | Hs.75431 | 10 | 15.0 |
| AASS | Aminoadipate-semialdehyde synthase | 7q31.3 | Hs.433075 | 10 | 13.8 |
| MGST1 | Microsomal glutathione S-transferase 1 | 12p12.3-p1 | Hs.389700 | 10 | 10.9 |
| GDF3 | Growth differentiation factor 3 | 2p13.1 | Hs.86232 | 10 | 9.5 |
| HSPA4 | Heat shock 70kDa protein 4 | 5q31.1-q31 | Hs.90093 | 10 | 9.2 |
| PHF17 | PHD finger protein 17 | 4q26-q27 | Hs.12420 | 10 | 9.2 |
| UNG | Uracil-DNA glycosylase | 12q23-q24. | Hs.191334 | 10 | 6.7 |
| USP9X | Ubiquitin specific peptidase 9, X-linked | Xp11.4 | Hs.77578 | 10 | 5.7 |
| CEBPZ | CCAAT/enhancer binding protein zeta | 2p22.2 | Hs.135406 | 10 | 5.4 |
| CRMP1 | Collapsin response mediator protein 1 | 4p16.1-p15 | Hs.135270 | 10 | 5.3 |
| BMPR1A | Bone morphogenetic protein receptor, type IA | 10q22.3 | Hs.524477 | 10 | 5.1 |
| ORC1L | Origin recognition complex, subunit 1-like (yeast) | 1p32 | Hs.17908 | 10 | 3.9 |
£
Chromosomal location.
§
Ratio of mean expression in hESC samples to mean expression in non-hESC samples.