Table 1.

The case information and PGD results

Reference	Case	Maternal age	Pregnancy times (DS pregnancies)	Parental karyotypes	Cycle	Oocytes			Biopsy diagnosis	Transferred	Outcome
						Collected	Fertilized	Biopsied
Conn et al. (1998)	1a	31	4 (3)	45, XX, der (13; 21) (q10; q10)	1	11	8	6	2 normal	Yes	NP
									2 monosomy 21, 13	No
									1 monosomy 21	No
									1 monosomy 13	No
					2	14	10	5	2 monosomy 21, 13	No
									1 tetrasomy 21	No
									1 trisomy 21	No
									1 unconclusive	No
Conn et al. (1999)	2	36	4 (3)	Normal	1	31 (total)	13 (total)	2	2 trisomy 21	No	NP
					2			3	2 normal	Yes
									1 trisomy 21	No
	3	32	5 (1)	46, XX, t (6;21) (q13; 22.3)	1	32 (total)	11 (total)	4	1 normal	Yes	ABP
									2 trisomy 21	No
									1 monosomy 21	No
					2			0
Scriven et al.(2001)	4b	39	2 (1)	45, XX, der (14; 21) (q10; q10)	1	11	7	5	3 normal	Yes	NP
									1 normal	No
									1 trisomy 21, 14	No
					2	15	10	9	3 normal	Yes	OHC
									1 trisomy 21	No
									1 monosomy 21	No
									1 trisomy 14	No
									1 monosomy 14	No
									2 unconclusive	No
Luo et al. (2002)	5	30	1 (1)	Normal	1	14	13	8	3 normal	Yes	OHC
									3 normal	No
									1 trisomy 21	No
									1 no signal	No
Author’s cases	6 (case 1)	43	3 (2)	Normal	1	3	2	2	1 trisomy 21	No
									1 monosomy 21	No
	7 (case 2)	30	2 (2)	Normal	1	10	8	8	2 normal	Yes	NP
									3 trisomy 21	No
									1 monosomy 21	No
									2 unconclusive	No
					2	17	14	8	2 normal	Yes	NP
									3 trisomy 21	No
									3 unconclusive	No

^aProbes: Locus-specific indicator (LSI) 13 and 21

^bProbes: LSI 21 and a biotinylated 14q subtelomere probe

NP: No pregnancy; OHC: One healthy child; ABP: A biochemical pregnancy