TABLE III.
Percent Abnormal in Detroit Sample by Different Iron Status Criteria
| NHANES II
|
NHANES III
|
Sweden/Honduras
|
|||||
|---|---|---|---|---|---|---|---|
| n | Cutoff | % Abnormal (n) | Cutoff | % Abnormal (n) | Cutoff | % Abnormal (n) | |
| Individual iron measures | |||||||
| Hb (g/l) | 198 | <110 | 25.3 (50)a | <110 | 25.3 (50)a | <100 | 1.5 (3)a |
| MCV (fl)b | 198 | <74 | 23.2 (46) | NA | <71 | 8.6 (17) | |
| FEP (μg/dl red blood cells) [μmol/mol heme] | 172 | >80 [>69] | 52.3 (90) | >80 [>69] | 52.3 (90) | >103 [>90] | 23.3 (40) |
| Transferrin saturation | 141 | <12 | 7.8 (11) | <10 | 5.0 (7) | NA | |
| Ferritin (μg/l) | 147 | NA | <10 | 4.8 (7) | <5 | 1.4 (2) | |
| TfR (mg/l) | 145 | NA | NA | >11 | 0.7 (1) | ||
| Iron deficiency/iron deficiency anemia (n) | 132c | 132c | 198 | ||||
| Iron deficiency (≥2 abnormalities) | 14.4 (19) | 5.3 (7) | 2.5 (5) | ||||
| Anemia + iron deficiency | 6.1 (8) | 2.3 (3) | 1.5 (3) | ||||
a
Values in parentheses indicate number of cases.
b
As recommended by the CDC (26), the MCV cut-off was 74 fl (instead of 73 fl) to reflect changes in methods for determining hematocrit and possibly red cell counts.
c
The n for estimating the proportion with iron deficiency or iron deficiency anemia using NHANES criteria was based on infants with complete data for Hb, MCV, FEP, transferrin saturation, and ferritin.