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. Author manuscript; available in PMC: 2008 Mar 1.
Published in final edited form as: Bioorg Med Chem. 2007 Jan 4;15(5):1939–1946. doi: 10.1016/j.bmc.2007.01.004

Figure 6.

Figure 6

Induced degradation of Hsp90 client proteins via compounds 9 (upper panel) and 15 (lower panel). The compounds, at varying concentrations, (μM) were evaluated for their ability to downregulate Her2, Akt and Raf-1 as described in the methods section. Geldanamycin (GA, 500 nM) and DMSO were used as positive and negative controls, respectively.