Induced degradation of Hsp90 client proteins via compounds 9 (upper panel) and 15 (lower panel). The compounds, at varying concentrations, (μM) were evaluated for their ability to downregulate Her2, Akt and Raf-1 as described in the methods section. Geldanamycin (GA, 500 nM) and DMSO were used as positive and negative controls, respectively.