Table 3.
Neuro-developmental impairments at 18–24 months of age in early iNO and control Infants
| Variable | Early iNO (121) | Control (113) | p- value | 95% Confidence Interval for the difference |
|---|---|---|---|---|
| Cerebral palsy-all degree – n (%) | 10 (8.2) | 7 (6.3) | 0.58§ | −9.0, 5.3 |
| Cerebral palsy-moderate to severe-n (%) | 6 (4.9) | 3 (2.7) | 0.50* | −8.2, 3.6 |
| Any neurologic abnormality- n (%) | 20 (16.4) | 10 (9.2) | 0.10§ | −16.0, 1.5 |
| Moderate/severe neurologic abnormality-n (%) | 6 (4.9) | 3 (2.8) | 0.51* | −8.0, 3.5 |
| Bayley MDI – mean/median (SD) | 83.3/87 (21.0) | 86.1/90 (19.9) | 0.28# | −8.0, 2.0Ψ |
| MDI < 70- n (%) | 28 (25.2) | 24 (22.9) | 0.68§ | −13.7, 9.1 |
| Bayley PDI – mean/median (SD) | 89.0/93 (17.7) | 93.5/98 (18.4) | 0.009# | −9.0, −1.0Ψ |
| PDI < 70- n (%) | 13 (11.9) | 12 (11.4) | 0.91§ | −9.4, 8.5 |
| Blind unilateral- n (%) | 1 (0.8) | 1 (0.9) | 1.0* | −3.9, 4.4 |
| Bilateral | 4 (3.4) | 1 (0.9) | 0.37* | −7.7, 2.2 |
| Hearing status – n (%): | ||||
| Normal hearing | 79 (76.7) | 76 (76) | 0.91§ | −12.5, 11.0 |
| Sensorineural loss | 7 (6.8) | 10 (10.0) | 0.41§ | |
| Conductive loss | 16 (15.5) | 7 (7.0) | 0.055§ | |
| Undetermined/other | 1 (0.97) | 7 (7.0) | 0.03* | |
| Hearing impairment requiring amplification | 1 (1.0) | 3 (3.0) | 0.37* | |
| Seizure disorder- n (%) | 4 (3.4) | 4 (3.7) | 1.0* | |
| Hydrocephalus with shunt- n (%) | 0 (0) | 0 (0) | ||
| Any neuro-developmental impairment (NDI)- n (%) | 34 (27.9) | 28 (24.6) | 0.56§ | −14.5, 8.0 |
*
by Fisher exact test; # by Wilcoxon test;
§
by Chi-square test,
Ψ
CI are for difference in medians for these variables