Table 1.
Comparison between the Detection of Chromosome 3 Imbalances by FISH and Classical Cytogenetics within Lung Cancer Samples
| Case | Interphase imbalance (Ii) | Metaphase imbalance (IM) | |
|---|---|---|---|
| R-banding | FISH | ||
| SCLC6 | 1.7 | 1.7 | 1.7 |
| SCLC10 | 1.7 | 1.7 | 1.7 |
| SCLC41 | 2 | 2 | 2 |
| SCLC74 | 1.7 | 1.7 | 1.7 |
| SCLC108 | 2 | 2 | 2 |
| SCLC110 | 1.3 | * | >1 |
| SCLC130 | 1.5 | 1.5 | 1.5 |
| SCLC131 | 1.3 | N.D. | N.D. |
| NSCLC1 | 1.7 | 1.5<l<2 | 1.5<l<2 |
| NSCLC3 | 1.5 | >1 | 1.5 |
| NSCLC4 | 1 | 1 | N.D. |
| NSCLC9 | 1 | N.D. | N.D. |
| NSCLC8 | 1.3 | 1 and 1.5 | N.D. |
| NSCLCIC8 | 1.8 | N.D. | N.D. |
| EFF1† | 1.3 | 1 and 1.5 | 1 and 1.5 |
| EFF2† | 1 | N.D. | N.D. |
| EFF2‡ | 1 | N.D. | N.D. |
| EFF3† | 1.5 | N.D. | N.D. |
| EFF3‡ | 1.5 | N.D. | N.D. |
Karyotype too complex for imbalance determination.
Cultured sample.
Directly fixed sample without culturing.
SCLC, small-cell lung cancer; NSCLC, non-small-cell lung cancer; EFF, pleural effusion; N.D., not determined due to lack of metaphases; I, imbalance.