Figure 5.

Clinical correlations in selected patients with high EBV levels. EBV levels were determined by ICS-PCR in samples from two representative patients that showed relatively high EBV levels. EBV levels are plotted against the time the sample was harvested after organ transplantation. Open symbol indicates sample in which no viral band was detected; viral burden represents the limits of detection for that PCR reaction. The significant clinical findings are as follows. A: Patient 17. a: Cyclosporin levels were increased. b: Mild gastrointestinal symptoms developed; the patient was treated with intravenous prednisone. c: Mild lymphadenopathy was noted on chest X-ray. Treatment with ganciclovir and cytogam was begun. Immunosuppression was reduced slightly. d: Patient presented with gastroenteritis. e, f: CT scans show increasing lymph node size and number. B: Patient 5. g: Patient was admitted to hospital with complaints of nausea, vomiting, and diarrhea. h: Patient was admitted to hospital with pneumonia. Elevated liver enzymes were noted. High EBV and CMV IgG were detected by serological evaluation. i: Immunosuppression was tapered down threefold.